Hemp 101: What is CBD Used For, Hemp History and Medical Studies

• Facts
• Hemp History
• Medical Studies

• Betsy Ross made the first American Flag on Hemp cloth for the Republic.

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• Patent No. 6,630,507 was taken out for the medicinal use of cannabis by the United State Department of Health and Human Services. Inside the registered patent HHS claims that there is potential use for the non-psychoactive cannabinoids in cannabis for diseases such as cirrhosis, and cannabinoids could be used to protect the brain from damage or deterioration.

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• "Hemp was entirely legal for the first 162 years of America’s existence until it’s demonization in 1930’s at the hands of Harry Anslinger, the first commissioner of the Treasury Department’s Federal Bureau of Narcotics (FBN) coined it: “the devil’s weed with roots in hell.” Dude. At Anslinger’s urging, the government rebranded hemp by calling it by its Mexican name “marijuana,” in hopes to scare the public into supporting the Hemp Prohibition. (Anslinger was a known racist and a staunch supporter of the prohibition, spouting hateful propaganda like “Reefer makes darkies think they’re as good as white men”)." [1]
• [1] Welstman, Y (2016, June 16). The U.S. Declaration of Independence Wasn’t Written on Hemp. (But New Declarations Should Be). Retrieved from https://israel-cannabis.com/2016/06/15/the-u-s-declaration-of-independence-wasnt-written-on-hemp-but-new-declarations-should-be/

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• The use of hemp cord in pottery identified at ancient village site dating back over 10,000 years, located in the area of modern day city of Taiwan. ​

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• The famous writings written on hemp paper include: The Gutenberg Bible (15th century); The King James Bible (17th century); Thomas Paine's pamphlets: The Rights of Man, Common Sense, andThe Age of Reason; The works of Mark Twain, Alexander Dumas, and Victor Hugo; and
  Lewis Carroll's beloved Alice in Wonderland. 

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• Paper made out of hemp is of much greater quality and durability than that made out of cotton, and it lasts longer. During Colonial times, a few hundred years ago, bibles, maps, paper money, stocks & bonds, and newspapers were all printed or written on hemp paper. 

• The USA is the only industrialized country that banned the cultivation of industrial hemp in 1970. Slowly the laws in the USA are changing to allow farmers to grow hemp! The 10 states that have already passed laws allowing hemp production are California, Colorado, Kentucky, Maine, Montana, North Dakota, Oregon, Vermont, Washington, and West Virginia, and the vote comes as even more states are showing an interest in hemp. 

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• Hemp is a robust plant, and requires no herbicides or pesticides grow and the seeds cannot be genetically modified.

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• Hemp seeds are considered the “perfect food” and contain all 20 Amino Acids, including the 8 Essential Amino Acids and a naturally balanced 1:3 ratio of Omega-3 and Omega-6 Essential Fatty Acids.

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• “The oil seed varieties most commonly grown for food can grow up to 10-15 feet tall within 90-120 days.”

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• Hemp is a profitable and potential “multi-income” crop for cultivators and harvesters, as both seeds, oil and fiber can be processed.

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• Hemp is a highly valuable crop with oil, seed and fiber varieties that can be used for over 25,000 of useful everyday products, for example; fabrics, rope, paper, food, health and skin care, beauty products, printing inks, paint, and building materials.

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• Hemp can provide four times as much pulp for paper with at least 4-7 times less pollution than tree paper without ecological damage.

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• Presidents George Washington, Thomas Jefferson and Ben Franklin all grew Hemp on their farms.

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• No permit or prescription required for the purchase or consumption of CBD Hemp products.

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• CBD Hemp Oil is legal everywhere in all 50 states in the USA (and most other countries in the world).

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• CBD Hemp oil is not psychoactive
  You unequivocally CANNOT get "buzzed" or "intoxicated" by consuming CBD Hemp Oil or any whole, raw natural product from industrial hemp plants in any matter. Unlike “Medical Marijuana,” hemp CBD does not contain the psychoactive properties of THC.  It is well known in scientific research and the medical community at large that CBD is anti-psychoactive.

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• CBD does not produce a high when ingested or smoked, unlike THC. Due to hemp's lack of affinity for CB1 receptors, CBD is non-psychoactive. CB1 receptors are found in large numbers and concentrations in the brain, and are the pathways responsible for the psychoactive effects of THC. THC does have an affinity to CB1 receptors, and it's the attachment of the THC to these CB1 receptors, that produces the sensation of the "high" normally associated with marijuana. Industrial hemp and marijuana are not identical. Marijuana and hemp are different varieties of the same species of plant, Cannabis sativa L. There are different varieties of Cannabis, just as a flamingo and a pelican are of the same "class" of "Aves" but differ in their "order" where the pelican is from the order of Pelecaniformes and the flamingo is from the order of Phoenicopteriformes. Marijuana and hemp are scientifically different and cultivated in different ways. Marijuana is the flowering tops and leaves of psychoactive varieties of Cannabis that are grown for their high levels of THC.  

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• Cannabidiol (CBD) - is one of over 100 cannabinoids found in cannabis (of which THC is a cannabinoid as well). It is a major constituent of the plant, second to tetrahydrocannabinol (THC). Compared with THC, CBD is not psychoactive in individuals, and is considered to have a wider scope of medical applications than THC Currently CBD is being tested in medical laboratories all over the world to unlock the effects it has on conditions such as: epilepsy, multiple sclerosis spasms, anxiety disorders, bipolar disorder, schizophrenia, nausea, convulsion and inflammation, as well as inhibiting cancer cell growth. Other research indicates that CBD increases alertness. CBD has been shown to reduce growth of aggressive human breast cancer cells in vitro and to reduce their invasive nature.

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• Hemp produces 4 x's as much fiber per acre than pine trees.

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• Pine tree paper can be recycled up to 3 x's. However, hemp paper can be recycled up to 7 x's.

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• Hemp and humanity have co-existed in unison for over 10,000 years.

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• Prior to prohibition, hemp remained the largest crop on the planet. In fact, hemp was the very first agricultural crop in America.

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• Hemp farms were banned in the United States but continued all over the world. The countries of today leading the industrial hemp production are China, Russia, Hungary, England, Romania, France, Italy, Spain, Australia, Holland, Germany, Poland, Ukraine, India, Holland and Asia. 

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• Technically growing hemp is legal, the caveat being that growers must obtain a special permit to do so from the DEA. Very few people ever receive the permit and there are numerous rules necessitated to maintain the permit, such as, the crop must be guarded and surrounded by fencing, razor wire, security guards or watch dogs. 

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• Excavations have discovered hemp paper that was over 1,500 years old because hemp paper's fibers resists decomposition, therefore if an acid-free production was utilized the hemp paper does not yellow with age.

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• During WWII hemp was essential to the war effort. So the federal government of the United States subsidized American farmers hence over a million acres of hemp were grown using government subsidies.

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• Up until 1880s all schoolbooks were made of hemp or flax paper.

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• Between 1630 - 1880 it was perfectly legal to pay your taxes in hemp.

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• Benjamin Franklin initiated one of the first American paper mills for the production of hemp.

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• In 1941, Ford constructed a hemp fueled prototype car that was partially constructed from hemp composites.    

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• During the Colonial Period it was against the law NOT to grow hemp on your property. Hemp was required for the production of the sails on sail boats and for the rope needed on the ships. This was one of the main reasons why Americans were legally bound to grow hemp. Sails were also referred to as canvass. The word canvass is a derivative of the the word cannabis. 

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http://www.advancedholistichealth.org/history.html. 10,000-year History of Marijuana use in the World. Retrieved from http://www.advancedholistichealth.org/history.html. 

Frequently Asked Questions:

What Is Full Spectrum CBD Hemp Oil by CTFO and How Does It Work?

• Cannabidiol or CBD for short, is a chemical compound derived from industrial hemp. This all-natural botanical concentrate in liquid form called CBD hemp oil, includes the cannabinoids and the fatty acids found in hemp plants. Full spectrum hemp oil gives you more than just the typical “hemp” compounds – it gives you powerful results. CBD hemp oil is not only safe, but it can provide numerous ANTIOXIDANT, ANTI-INFLAMMATION AND NEUROPROTECTIVE benefits.

• ​Hemp is considered to be a Super Food, it offers a complete spectrum of natural proteins, with all 20 amino acids used in the human body, including all eight essential ones. 
• Full spectrum CBD oil contains the perfect ratio of omegas - 3, 6, & 9 and has approximately 85 known naturally indigenous cannabinoids including CBD, CBG, CBN, CBC, CBL, and CBV to name a few...(SEE CANNABINOID CHART AT THE BOTTOM OF THIS PAGE).
• CBD Hemp has high levels of enzymes, fiber, vitamins A, B1, B2, B6, C, D, and E and is rich in essential minerals such as calcium, zinc, iron, magnesium, manganese, and phosphorus. CBD is packed full of natural carotenes, flavonoids, keytones, nitrogenous compounds and terpenes. 

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 Can Hemp Oil Make Someone High?:

• CBD contains .03% THC or less by law and is not psychotropic, meaning it does not produce the “high” associated with marijuana. It is thus considered THC-Free and is legal in all 50 states.

How Does the Non-THC Hemp CBD Operate Inside the Human Body to Create Its Benefits?:

• CBD interacts with and supports the body’s endogenous and endocannabinoid system. This system plays a crucial role our well-being. Endocannabinoids and their receptors are everywhere in the body – from organs to cells. The endocannabinoid system performs various functions, but the goal is always homeostasis or balance, maintaining a stable internal environment to counteract variations in the external environment.

What Are Botanical Terpenes?

• Terpenes are the fragrant oils that give botanical plants and flowers like Cannabis their aromatic diversity. Along with being responsible for the aromas of botanical plants, terpenes also interact with the psychological effects associated with those aroma.​​ ​
• The FDA and other agencies have generally recognized terpenes as “safe.” Terpenes act on receptors and neurotransmitters; they are prone to combine with or dissolve in lipids or fats; they act as serotonin uptake inhibitors; they enhance norepinephrine activity; they increase dopamine activity; and they augment GABA (the “downer” neurotransmitter that counters glutamate, the “upper”).​

What Are Cannabinoids?

• Cannabinoids are chemical compounds that act on cannabinoid receptors in the brain. The most well-known cannabinoids include THC, CBD, CBN and THCa. However, the CTFO brand of Hemp CBD is virtually free of the cannabinoid, THC.

General Guide On CBD​​: 
The CBD User's Manual: Everything You Need to Know About Marijuana's Most Medicinal Molecule

Newsfeed Information on CBD Hemp and Studies Related to Medical Symptoms-

All the Articles Below Were Compiled by: Project CBD
A Non-Profit Organization Dedicated to Learning More About CBD Treatments:

CBD for ACNE
Acne and CBD Hemp Oil Research

• The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content
• CBD as a Treatment for Acne?
• CBD exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease
• Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
• Endocannabinoid signaling and epidermal differentiation
• Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions

CBD for ADD & ADHA & HYPERACTIVITY & ATTENTION DISORDERS
Hyperactivity & Attention Disturbances and Cannabinoids

• Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders
• CBD and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats
• Subtypes of ADHD and cannabis use
• Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students
• Oral delta 9-THC improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition
• Fitness to drive in spite (because) of THC
• ADHD Is Highly Prevalent in Patients Seeking Treatment for Cannabis Use Disorders
• A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD
• Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial

CBD for ADDICTIONS TO DRUGS & ALCOHOL
Addictions and CBD Research

• CBD as an Intervention for Addictive Behaviors 
• CBD reduces cigarette consumption in tobacco smokers
• Inhibition of monoacylglycerol lipase enzyme reduces nicotine withdrawal
• CBD inhibits the reward-facilitating effect of morphine 
• Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances 
• Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats 
• Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment
• Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010
• Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
• Comparison of CBD, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity
• Transdermal delivery of CBD attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
• CBD for the treatment of cannabis withdrawal syndrome
• Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents
• CBD Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway
• CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders​

CBD for ALZHEIMER'S & DEMENTIA
​Memory Loss and Cannabinoid Research

• Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease
• The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
• Endocannabinoid signalling in Alzheimer’s disease
• A molecular link between the active component of marijuana and Alzheimer’s disease pathology
• Neuroprotective effect of CBD... on beta-amyloid-induced toxicity in PC12 cells
• The Potential Therapeutic Effects of THC on Alzheimer’s Disease
• The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease 
• Cannabinoids for the treatment of dementia
• CBD in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression 
• CBD: A promising drug for neurodegenerative disorders?
• Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
• The role of the endocannabinoid system in Alzheimer’s disease 
• The role of phytochemicals in the treatment and prevention of dementia 
• Cannabinoids for the treatment of dementia  
• Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic  
• Can Marijuana Prevent Alzheimer’s?  
• Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia
• Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer's Disease
• Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
• Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model
• CBD Modulates the Expression of Alzheimer’s Disease-Related Genes in Mesenchymal Stem Cells

CBD for ANXIETY & STRESS
Medical Research Publications

• A Systematic review of plant-derived natural compounds for Anxiety Disorders
• Does Cannabidiol Protect Against Adverse Psychological Effects of THC?
• Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence
• Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives

CBD for Anxiety News Articles

• Distinct Effects of ?9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
• What studies say about Hemp CBD
• CBD Oil for Anxiety: Is Cannabidiol an Effective Treatment?
• Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test
• Endocannabinoid system and mood disorders: Priming a target for new therapies
• Effects of Cannabidiol (CBD) on Regional Cerebral Blood Flow
• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
• Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients

CBD for Anxiety Videos

• Dr. Allan Frankel on Anxiety and Cannabidiol
• CBD Gum Canchew helps Anxiety Depersonolization Derealization​

• CBD as an anxiolytic drug
• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
• CBD reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
• Neural basis of anxiolytic effects of CBD in generalized social anxiety disorder
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
• Effects of CBD on regional cerebral blood flow
• The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1Areceptors 
• The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• Plant-based medicines for anxiety disorders, part 2 
• A systematic review of plant-derived natural compounds for anxiety disorders
• The Endocannabinoid System and Anxiety
• CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
• Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats

CBD for Stress and CBD Research

• CBD Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
• Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies  
• Cannabinoids and bone: Friend or foe?  
• Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells  
• Cannabinoids and the skeleton: From marijuana to reversal of bone loss  
• The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy 
• The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption  
• Endocannabinoids and the regulation of bone metabolism  
• Cannabinoid receptors and the regulation of bone mass 
• Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health  
• Peripheral cannabinoid receptor, CB2, regulates bone mass  
• Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors 
• Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis  
• Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family  

CBD for ARTHRITIS & RHEUMATISM
CBD oil and arthritis medical research

• The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.
• Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw.
• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.
• Therapeutic potential of cannabinoid-based drugs.
• Involvement of the Endocannabinoid System in Osteoarthroid Pain
• Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.

CBD oil and News Articles

• Cannabis and Arthritis: THC and CBD to the Rescue
• Medical Cannabis for Rheumatoid Arthritis?
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
• The use of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.
• Cannabidiol (CBD): Fighting Inflammation & Aggressive Forms of Cancer
• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
• Cannabis constituent cannabidiol is an oral anti-arthritic therapeutic
• Rheumatoid Arthritis-NORML
• CBD Weekly: CBD and Arthritis
• Medical Cannabis Can Help Arthritis Patients

CBD oil and arthritis video

• Rheumatoid Arthritis patient explains How Cannabis Benefits his Life!!

• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis 
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
• Involvement of the endocannabinoid system in osteoarthritis pain 
• The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 

Rheumatoid Arthritis

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress 

CBD for AUTISM
NEW! Israeli CBD oil and Autism Clinical Trial - Read more HERE

CBD oil and autism medical research

• Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
• A novel approach to the symptomatic treatment of autism
• Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders
• Targeting the endocannabinoid system in the treatment of fragile X syndrome

CBD oil and autism articles

• Cannabis spray treatment helps 9-year-old with Autism learn to speak
• Cannabidiol seems to help with autism in young patients
• What happened when they treated autistic children with medical cannabis
• Cannabidiol might help treat autism
• Desperate parents of autistic children trying cannabis
• Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
• The autism and compassionate care connection

CBD oil and autism videos

• Medical cannabis used to treat autistic children
• Can Cannabidiol reverse autism?

Forum Postings

• I gave my autistic son cannabis oil
• Parents for Medical Cannabis-Kentucky

Endocannabinoids and Autism

• Endocannabinoid Signaling in Autism
• Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
• Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
• A novel approach to the symptomatic treatment of autism
• Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders 
• Targeting the endocannabinoid system in the treatment of fragile X syndrome
• Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling

CBD for BONE DISEASE & OSTEOPOROSIS 
Bone Fractures

• Scientists Discover Marijuana Helps Heal Broken Bones, & Even Makes Them Stronger
• "We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue," said Dr. Gabet. "After being treated with CBD, the healed bone will be harder to break in the future."
• CBD and Bone Fractures Medical Study
• Studies Suggest Cannabis can Treat Broken Bones and Bone Diseases
• No bones about it: Cannabis may be used to treat fractures​

​Cannabinoids and the Skeleton

• CBD Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
• Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies  
• Cannabinoids and bone: Friend or foe?  
• Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells  
• Cannabinoids and the skeleton: From marijuana to reversal of bone loss  
• The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy 
• The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption  
• Endocannabinoids and the regulation of bone metabolism  
• Cannabinoid receptors and the regulation of bone mass 
• Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health  
• Peripheral cannabinoid receptor, CB2, regulates bone mass  
• Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors 
• Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis  
• Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family  

CBD for CANCER
CBD oil and Cancer Articles
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• Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect.
• Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.
• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.
• Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
• Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• Cannabinoids for Cancer Treatment: Progress and Promise
• Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
• Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabis and Cancer, Pt. 3: How THC and CBD work on cancer cells
• Cannabis and Cannabinoids – National Cancer Institute
• Pot compound seen as tool against cancer
• Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.
• How Cannabinoids Kill Cancer - Dennis Hill

CBD oil and Cancer Videos

• Marijuana And Cancer
• Medical Marijuana Stops Spread of Breast Cancer – NBC NEWS
• Cannabis vs Cancer Dr. Sanjay Gupta CNN – The CBD Discovery
• Watch what happens when Cannabis Oil is injected into Cancer cells
• Medical Marijuana Patient releases photos of massive tumors
• The Seth Group - The Action of Cannabinoids in Cancer Cells​

CANCER & CBD BY CATEGORY:
General

• CBD as potential anticancer drug  
• CBD inhibits angiogenesis by multiple mechanisms  
• The inhibitory effects of CBD on systemic malignant tumors
• CBD inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
• Marijuana fights cancer and helps manage side effects  
• In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
• The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion
• Antitumorigenic targets of cannabinoids - current status and implications
• Cannabinoids - a new weapon against cancer?

Bladder

• TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Brain

• Cannabidiol enhances the inhibitory effects of delta9-THC on human glioblastoma cell proliferation and survival  
• Antitumor effects of CBD, a nonpsychoactive cannabinoid, on human glioma cell lines  
• Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas  
• CBD inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism  
• Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target  
• Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents  
• CBD inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect  
• Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
• Synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture
• Cannabis improved survival of patients with aggressive brain cancer in controlled clinical study

Breast

• Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
• CBD induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy  
• Pathways mediating the effects of CBD on the reduction of breast cancer cell proliferation, invasion, and metastasis  
• CBD as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells  
• Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
• CBD-A mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells

Colon

• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer  
• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of CBD  
• Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Endocrine

• Endocannabinoids in endocrine and related tumours  
• A comparative study on CBD-induced apoptosis in murine thymocytes and EL-4 thymoma cells

Kaposi Sarcoma

• CBD inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium

Leukemia

• CBD-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression  
• CBD-Induced Apoptosis in Human Leukemia Cells  
• Cannabidiol Reduces Leukemic Cell Size - But Is It Important?  

Lung

• CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C  
• COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells  
• Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of CBD on human lung cancer cells  
• Media ignored expert’s shocking findings that marijuana helps prevent lung cancer  

Pain

• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain  
• Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial  
• Marijuana extract helps prevent chemo pain

Prostate

• Towards the use of non-psychoactive cannabinoids for prostate cancer  
• In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines
• Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Skin

• Anticancer activity of anandamide in human cutaneous melanoma cells   

CBD for COLITIS & CROHN'S DISEASE & IRRITABLE BOWEL SYNDROME 
​Colitis and Crohn’s and CBD

• CBD in inflammatory bowel diseases: a brief overview  
• Cannabis finds its way into treatment of Crohn’s disease 
• CBD reduces intestinal inflammation through the control of neuroimmune axis 
• Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis  
• The effects of Delta-tetrahydrocannabinol and CBD alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis  
• Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice  
• Cannabinoids and the gut: New developments and emerging concepts 
• Endocannabinoids and the gastrointestinal tract  
• Cannabinoids and gastrointestinal motility: Animal and human studies  
• Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis  
• Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review  
• Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial.  

CBD for Irritable Bowel Syndrome

• Cannabidiol in inflammatory bowel diseases: A brief overview  
• CBD reduces intestinal inflammation through the control of neuroimmune axis  
• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?  
• Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation  
• Therapeutic potential of cannabinoid-based drugs  
• Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)  
• CBD and the gut: New developments and emerging concepts  
• Endocannabinoids and the gastrointestinal tract  
• CBD and gastrointestinal motility 
• Getting into the weed: the role of the endocannabinoid system in the brain-gut axis

• Cannabidiol in inflammatory bowel diseases: A brief overview  
• CBD reduces intestinal inflammation through the control of neuroimmune axis  
• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?  
• Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation  
• Therapeutic potential of cannabinoid-based drugs  
• Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)  
• CBD and the gut: New developments and emerging concepts  
• Endocannabinoids and the gastrointestinal tract  
• CBD and gastrointestinal motility 
• Getting into the weed: the role of the endocannabinoid system in the brain-gut axis
• Cannabinoids and GI Disorders: Endogenous and Exogenous

CBD for DEPRESSION
CBD Oil and Depression Medical Research

• Antidepressant-like and Anxiolytic-like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
• The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders
• Endocannabinoid System Dysfunction in Mood and Related Disorders

CBD Oil and Depression News

• CBD relieves Depression faster than any other Anti-Depressant
• Cannabis as a treatment for Depression
• Home Remedies for Depression
• All in the Mind #4: How Cannabis Treats Depression
• CBD Relieves Depression Faster than Any Other Anti-Depressant

Depression and CBD Oil

• Endocannabinoid system dysfunction in mood and related disorders  
• Antidepressant-Like and Anxiolytic-Like Effects of CBD
• The endocannabinoid system and the treatment of mood and anxiety disorders  
• Endocannabinoid signaling in the etiology and treatment of major depressive illness  
• Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors  
• Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants  
• Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa  
• Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress 
• Serum contents of endocannabinoids are correlated with blood pressure in depressed women  
• The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants  
• Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures  
• Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors
• Prohedonic Effect of CBD in a Rat Model of Depression  
• Antidepressant-like and anxiolytic-like effects of CBD  

CBD for DIABETES & HIGH BLOOD GLUCOSE/SUGAR
Diabetes and CBD Research

• Diabetes Home / CBD-Conditions Relieved by Cannabidiol
• The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
• CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• CBD lowers incidence of diabetes in non-obese diabetic mice  
• Neuroprotective and blood-retinal barrier-preserving effects of CBD in experimental diabetes 
• Cannabidiol arrests onset of autoimmune diabetes in NOD mice  
• Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation  
• Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes  
• The endocannabinoid system in obesity and type 2 diabetes  
• Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes  
• The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications  
• Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain  
• Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats 
• Efficacy and Safety of CBD and THC-V on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes ​
• The impact of marijuana use on glucose, insulin, and insulin resistance among US adults  
• The potential use of cannabidiol in the therapy of metabolic syndrome 
• Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes  

CBD for EYE DISEASE & DISORDERS
CBD and Eye Health Research

• ​Retinal Damage – Medical Marijuana Research Overview

CBD for FIBROMYALGIA​
Fibromyalgia and CBD Research

• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?  
• Cannabis use in patients with fibromyalgia 
• Cannabinoids for fibromyalgia

CBD for GENERAL HEALTH & CANNABINOIDS
General Health Benefits of CBD

• Safety and side effects of cannabidiol
• CBD: From an inactive cannabinoid to a drug with wide spectrum of action
• CBD as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
• CBD: An overview of some pharmacological aspects
• CBD: An overview of some chemical and pharmacological aspects
• The endocannabinoid system as an emerging target of pharmacotherapy
• Therapeutic potential of cannabinoid-based drugs
• Targeting the endocannabinoid system with cannabinoid receptor agonists
• Cannabis-based medicines–GW pharmaceuticals
• The therapeutic potential of cannabis and cannabinoids 
• Emerging strategies for exploiting cannabinoid receptor agonists as medicines
• Therapeutic potential of cannabinoid-based drugs
• Cannabinoids in clinical practice
• Cannabinoids
• Pharmacology of cannabinoids
• Combined cannabinoid therapy via an oromucosal spray
• Non-psychotropic plant cannabinoids
• Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology 
• Care and feeding of the endocannabinoid system
• Understanding the molecular aspects of THC and CBD as antioxidants 
• A tale of two cannabinoids 
• Clinical Studies With Cannabis and Cannabinoids, 2005-2009

CBD for GLAUCOMA
​Glaucoma and CBD Research

• Neuroprotective effect of (-)Delta9-THC and CBD in N-methyl-D-aspartate-induced retinal neurotoxicity 
• Effect of sublingual application of cannabinoids on intraocular pressure

CBD for HEADACHES & MIGRAINES​
Studies on Headaches and the Endocannabinoid Deficiency

• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?  
• Effects of anandamide in migraine: data from an animal model  
• Cannabinoids and hallucinogens for headache  
• The endocannabinoid system and migraine 
• Variations in the cannabinoid receptor 1 gene predispose to migraine  

CBD for HEART DISEASE
CBD and Heart Heath Research

• CBD as an anti-arrhythmic, the role of the CB1 receptors  
• Is the cardiovascular system a therapeutic target for CBD?  
• Acute administration of CBD in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion  
• CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy  
• The Effect of CBD on Ischemia/Reperfusion-Induced Ventricular Arrhythmias 
• CBD protects against myocardial ischemic reperfusion injury  
• Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension  
• Oleamide: A fatty acid amide signaling molecule in the cardiovascular system? 
• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis

CBD for HUNTINGTON'S DISEASE​
Neuroprotective Attributes of CBD on Huntington's Disease Research

• Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease 
• Cannabinoids: Novel medicines for the treatment of Huntington’s disease  
• Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB(1) and CB(2) receptors  
• Controlled clinical trial of cannabidiol in Huntington’s disease  
• Prospects for cannabinoid therapies in basal ganglia disorders  
• Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice  
• Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington’s Disease  
• Neurological aspects of medical use of CBD

CBD for INFLAMMATION & SWELLING
Inflammation of Body Parts and CBD Research

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
• Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice  
• The endocannabinoid system: an emerging key player in inflammation 
• ​Cannabinoids, endocannabinoids, and related analogs in inflammation  
•  ​Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor 
• ​​Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors  
• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis  
• Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation  
• Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement  
• Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption  
• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation  
• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death 
• Cannabinoids in clinical practice  
• Pure THC-V inhibits nitrite production in murine peritoneal macrophages
• Cannabinoids, inflammation, and fibrosis
• Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
• Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain
• Protective effect of CBD on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cell

CBD for Elevated Sebum Production and Inflammation of the Sebaceous Glands

• The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content
• CBD as a Treatment for Acne?
• CBD exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease
• Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
• Endocannabinoid signaling and epidermal differentiation
• Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions

CBD for KIDNEY DISEASE

• CBD attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death  ​

CBD for LIVER DISEASE & HEPATITIS & CIRROSIS​
Liver Disease, Cirrosis, and Hepatitis and CBD Research

• The endocannabinoid system and liver diseases  
• Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death  
• Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis  
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats 
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation ofTRPV1 receptors by cannabidiol  
• Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice  
• Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation  
• Potential of CBD for the Treatment of Viral Hepatitis

CBD for MULTIPLE SCLEROSIS​
Neurological Aspects of Cannabinoids on Multiple Sclerosis

• Sativex for the management of multiple sclerosis symptoms  
• THC & CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis  
• Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity  
• CBD provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors  
• Oromucosal delta9-THC/CBD for neuropathic pain associated with multiple sclerosis 
• Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis  
• Sativex long-term use: An open-label trial in patients with spasticity due to multiple sclerosis  
• A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis  
• Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain  
• Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain  
• Evaluating Sativex in Neuropathic Pain Management  
• CBD counteracted the development of experimental MS  
• CBD/THC Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice  
• Neurological aspects of medical use of CBD

CBD for NAUSEA
CBD and Nausea Research

• Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system
• CBD, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus  
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1Areceptor activation  
• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews  
• Regulation of nausea and vomiting by cannabinoids 
• CBD: its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats  
• Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting ​

CBD for PAIN
CBD Oil and Pain Management Medical Research

• Investigation of Cannabis for Chronic Pain and Palliative Care
• Cannabinoids in the management of difficult to treat pain
• An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics.
• A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.
• Pain relief with cannabinoids– the importance of endocannabinoids and cannabinoids for pain therapy
• Meta analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

CBD Oil and Pain Management News Articles

• Marijuana component could ease pain from chemotherapy drugs, study suggests
• Cannabis 101: THC and CBD
• Pain Management without Side Effects: Curing a Schedule II Habit with a Schedule I Plant​-Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
• How Hemp Oil is changing Chronic Pain Management
• 10 Benefits of CBD for Chronic Pain
• Success with CBD Oil

CBD Oil and Pain Management Videos

• Hemp oil and chronic back pain video

CBD and Chronic Pain Research

• ​Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain  
• Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain 
• Cannabis, pain, and sleep: Sativex Clinical Trials  
• Sativex successfully treats neuropathic pain characterised by allodynia: clinical trial  
• Cannabinoids for neuropathic pain  
• Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue  
• Oromucosal delta9-THC/CBD for neuropathic pain associated with multiple sclerosis 
• The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain  
• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation  
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy  
• Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain
• Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action  
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors  
• Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes  
• Cannabinoids in the management of difficult to treat pain  
• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability ofTHC:CBD extract and THC extract in patients with intractable cancer-related pain  
• Marijuana extract helps prevent chemo pain  
• Pot users less likely to take painkillers  
• CBD & THC interactions on acute pain and locomotor activity

CBD for PARKINSON'S DISEASE
Parkinson's Disease and the Cannabinoid Receptors to Control Tremors Research

• Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial 
• Prospects for cannabinoid therapies in basal ganglia disorders  
• Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: Importance of antioxidant and cannabinoid receptor-independent properties
• Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease  
• Cannabidiol  
• Cannabidiol for the treatment of psychosis in Parkinson’s disease  
• Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease  
• Therapeutic potential of cannabinoids in CNS disease  
• CB2 Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson’s Disease
• Neurological aspects of medical use of CBD

CBD for POST TRAUMATIC STRESS DISORDER - PTSD
PTSD and the Endocannabinoid System Research

• The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD 
• Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks  
• Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear  
• Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors  
• CBD blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors  
• Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis 
• Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence  
• Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment  
• The endocannabinoid system and extinction learning  
• A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers 
• Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit  
• Non-antidepressant long-term treatment in post-traumatic stress disorder  
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system  
• The Use of Medicinal Marijuana for Posttraumatic Stress Disorder: A Review
• CBD Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System
• Bidirectional Effects of CBD on Contextual Fear Memory Extinction

CBD for PETS
CBD and pets articles:

• Natures medicine: hemp derived CBD for anxious pets
• Denver news release: CBD for pets
• MG Magazine article Pg#1 Pg2
• High Times magazine article
• Treating seizures in pets with CBD (leafly article)
• CBD dog treats Real and amazing things (High Times article)
• The marijuana industries newest customers
• PETA: Article about pets and the use of cannabis
• Hemp CBD Oil and Treats are all the Rage; Can CBD benefit your dog?

CBD Oil and Pets Videos

• How to Safely Medicate your dogs with Cannabis

CBD for PSYCHOTIC & MOOD DISORDERS & SCHIZOPHRENIA
CBD oil for psychosis Medical Publications

• Cannabinoids and Schizophrenia: Therapeutic Prospects.
• Medical use of cannabis. Cannabidiol: a new light for schizophrenia?
• The yin and yang of cannabis-induced psychosis: the actions of ?(9)-tetrahydrocannabinol and cannabidiol in rodent models of schizophrenia.
• Potential protective effects of cannabidiol on neuroanatomical alterations in cannabis users and psychosis: a critical review.
• A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.
• Cannabidiol as a potential treatment for psychosis.

CBD oil for psychosis in News Articles

• Cannabidiol for Psychosis counteracting THC, which causes it
• Study: Cannabidiol Holds Promise For Treating Psychosis
• Marijuana Compound Treats Schizophrenia with Few Side Effects: Clinical Trial
• Marijuana Compound May Beat Antipsychotics at Treating Schizophrenia
• Antipsychotic Profile of Cannabidiol and Rimonabant in an Animal Model of Emotional Context Processing in Schizophrenia
• Antipsychotic-like Effects of Cannabidiol and Rimonabant: Systematic Review of Animal and Human Studies
• Cannabidiol Holds Promise for Treating Psychosis

CBD oil for psychosis videos

• Interview with Dr. Lester Greenspoon Talk about laws and the psychotic affects of marijuana
• CBD as an anti psychotic
• Cannabis & Psychosis: Robin Murray​
• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders  
• The endocannabinoid system & the treatment of mood and anxiety disorders 
• The endocannabinoid system & psychiatric disorders  
• The endocannabinoid system in the regulation of emotions throughout lifespan: A discussion on therapeutic perspectives  
• Endocannabinoid system dysfunction in mood and related disorders  
• Effects of CBD on regional cerebral blood flow  
• Cannabidiol, neuroprotection and neuropsychiatric disorders
• Therapeutic Potential of Cannabinoids in Psychosis
• Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?

CBD for Schizophrenia

• Cannabis Drug Shows Promise in Treating Schizophrenia
• CBD as an antipsychotic drug  
• Cannabidiol as a potential treatment for psychosis 
• CBD enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia  
• Medical use of cannabis. CBD: A new light for schizophrenia?
• A critical review of the antipsychotic effects of CBD: 30 years of a translational investigation
• Peripheral endocannabinoid system dysregulation in first-episode psychosis 
• Cannabinoids and schizophrenia 
• Antipsychotic-like effects of cannabidiol and rimonabant
• CBD monotherapy for treatment-resistant schizophrenia  
• Cannabis with high CBD content is associated with fewer psychotic experiences  
• Marijuana compound treats schizophrenia with few side effects: Clinical trial 
• Clearing the smoke: what do we know about adolescent cannabis use and schizophrenia?
• Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments 
• Improved Social Interaction, Recognition and Working Memory with CBD Treatment in a Prenatal Infection Rat Model. 

CBD for SEIZURES & EPILEPSY
Medical Publications & Research on Cannibidiol and Seizures & Epilepsy

• A Randomized Control Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex 
• Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.
• Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.
• Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.
• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
• Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

CBD Oil for seizures in the News

• Charlottes Web Untangling one of Colorados Biggest Cannabis Success Stories
• CURE Epilepsy: Research: Spotlight on CBD
• Study confirms safety of Cannabis drug CBD
• One Mans Desperate Quest to Cure his Son's Epilepsy-With Weed
• Cannabidiol for seizure control attracts growing numbers to Colorado
• CBD Approved for Childhood Epilepsy Study
• CBD for Epilepsy-EpilepsyU
• FDA Approves Investigational Trials Assessing Cannabidiol For Pediatric Epilepsy

CBD Oil for Seizure Videos

• Charlotte’s Web – CBD for Epilepsy
• Selected Media Examples of Pediatric Applications of Cannabidiol (CBD)
• Cannabidiol CBD Extract Stops Epileptic Seizures caused by Dravet Syndrome
• CBD Hemp Oil With Epilepsy Testimonial

​CBD for Brain and Body Convulsions

• CBD for children with Dravet’s and intractable seizures (Video)
• Report of a parent survey of CBD-enriched cannabis use in pediatric treatment-resistant epilepsy 
• Medicinal marijuana stops seizures, brings hope to a little girl  
• Cannabinoids for epilepsy  
• Cannabis, CBD, and epilepsy – From receptors to clinical response 
• The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability 
• Chronic administration of CBD to healthy volunteers and epileptic patients  
• Endocannabinoid system protects against cryptogenic seizures 
• Seizing an opportunity for the endocannabinoid system
• Cannabidiol: promise and pitfalls  
• Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatricdisorders 
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatrictreatment-resistant epilepsy  
• From the Editors: Cannabidiol and medical marijuana for the treatment of epilepsy 
• Cannabidivarin (CBDV) suppressespentylenetetrazole (PTZ)-inducedincreases in epilepsy-related gene expression  
• CBD exerts anti-convulsant effects in animal models of temporal lobe and partial seizures  
• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo  
• Hypnotic and antiepileptic effects of CBD
• The cannabinoids as potential antiepileptics 
• Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats  
• CBD Post-Treatment Alleviates Rat Epileptic-Related Behaviors
• Pharmacology of cannabinoids in the treatment of epilepsy
• Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection
• Report from a Survey of Parents Regarding the Use of Cannabidiol in Mexican Children with Refractory Epilepsy.
• Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy

CBD for SKIN DISORDERS & PSORIASIS​
Itiching Relief and Skin Disorders in Cannabinoid Studies

• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis  
• CBD exerts sebostatic and antiinflammatory effects on human sebocytes 
• The endocannabinoid system of the skin in health and disease 
• Epigenetic control of skin differentiation genes by phytocannabinoids  
• A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ  
• Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1  
• Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation  
• Attenuation of allergic contact dermatitis through the endocannabinoid system  
• Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus  
• The role of cannabinoids in dermatology  
• Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK

​CBD for SLEEP DISORDERS & INSOMNIA & NARCOLEPSY

Sleep Studies and the Cannabinoid System Research

• The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent  
• Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex   
• Effects of acute systemic administration of CBD on sleep-wake cycle in rats  
• Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults  
• CBD modulates sleep in rats 
• Endocannabinoid modulation of cortical up-states and NREM sleep  
• Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat  
• Endocannabinoid Signaling Regulates Sleep Stability
• Cannabis, Cannabinoids, and Sleep: a Review of the Literature

CBD for STROKE & TBI (TRAUMATIC BRAIN INJURIES)

• Stroke and Traumatic Brain Injury and CBD Research
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury  
• Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism  
• Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism  
• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function 
• Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice  
• Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance  
• CBD reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke

CBD for WEIGHT LOSS & OBESITY​
Severe Weight Loss and CBD Hemp (Cannabidiol)

• Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa
• The role of the endocannabinoid system in eating disorders: Neurochemical and behavioural preclinical evidence
• Cancer cachexia and cannabinoids

CBD for Obesity and CBD Studies

• The impact of marijuana use on glucose, insulin, and insulin resistance among US adults 
• Cannabinol and cannabidiol exert opposing effects on rat feeding patterns  
• Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?  
• The endocannabinoid system in obesity and type 2 diabetes  
• Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk  
• Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
• CBD promotes browning in 3T3-L1 adipocytes​

There are 85+ known cannabinoids in CTFO full spectrum CBD hemp oil. Below is a partial chart of a few important cannabinoids found in cannabis, courtesy of Wikipedia.org. https://en.wikipedia.org/wiki/Cannabinoid​ Click on the Image to Enlarge. Here is a chart of the most common health benefits of the most popular cannabinoids in CBD hemp oil.  ​Click on the Image to Enlarge.

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FDA Disclaimer:

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

CTFO and Marlene Flowersthe administrator of this website assume no responsibility for the improper use of and self-diagnosis and/or treatment using these products. Our products should not be confused with prescription medicine and they should not be used as a substitute for medically supervised therapy. If you suspect you suffer from clinical deficiencies, consult a licensed, qualified medical doctor. You must be at least 18 years old to visit our website and make product purchases.

We do not make any health claims about our CTFO products. Before taking our products, it’s wise to check with your physician or medical doctor. It is especially important for people who are: pregnant, chronically ill, elderly, under 18, taking prescription or over the counter medicines. None of the information on our website is intended to be an enticement to purchase and may not be construed as medical advice or instruction.

The use of any of our products for any reason, other than to increase general health & wellness, is neither, implied nor advocated by CTFO or by Marlene Flowers herein.

Promising Studies Are Happening for Future Medical Benefits of Cannabinoids on Many Conditions.
​CBD is Being Tested in Experimental Models for the Following Conditions Listed in the Chart Below :
CBD Oil is a Health Food Like Olive Oil With Nutritional Benefits Inherent in the Hemp Plant. CBD Is Not a Cure for Disease. 

*These statements have not been evaluated by the FDA (The Food and Drug Administration) and are not intended to diagnose, treat, or cure any disease.  Benefitsofcannabishempcbdoil.blogspot.com does not make medical claims of any kind and we do not promise any benefits or results from the use of our products. Results may vary from person to person depending on many factors including, but not limited to, a person's overall health, environmental issues, and diet and exercise regimes. ALWAYS CHECK WITH YOUR PHYSICIAN BEFORE STARTING A NEW DIETARY SUPPLEMENT PROGRAM OR SKIN REGIMEN. See full disclosure at the above. 

Here is a small excerpt from an article published in The British Journal of Clinical Pharmacology - Fernández-Ruiz J - Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J. © 2012 The British Pharmacological Society. Published on the PubMed website:

"Cannabidiol for Neurodegenerative Disorders: Important New Clinical Applications for this Phytocannabinoid? "Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anti-convulsant, anti-oxidant, anti-emetic, anxiolytic and anti-psychotic agent, and is therefore a potential medicine for the treatment of neuro-inflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia, respectively. The neuro-protective potential of CBD, based on the combination of its anti-inflammatory and anti-oxidant properties, is of particular interest and is presently under intense preclinical research in numerous neuro-degenerative disorders."

​CBD hemp oil products are non-narcotic and are not medicine. We do not make any claims of treatment or cures, or the prevention of any symptoms of a disease, condition or disorder. People with a variety of health challenges enjoy using our products. To search any particular disease or disorder yourself "google" keyword "CBD," or go to www.projectcbd.org for a comprehensive library of scientific medical reviews regarding the use of CBD.

People with the following conditions have enjoyed using CBD : Acne, ADD/ADHD, Addiction, AIDS, ALS, Alzheimer’s, Anorexia, Antibiotic resistance, Anxiety, Atherosclerosis, Arthritis, Asthma, Autism, Bipolar, Cancer, Colitis/Crohn’s, Depression, Diabetes, Endocrine disorders, Epilepsy/seizure, Fibromyalgia, Glaucoma, Heart disease, Huntington’s, Inflammation, Irritable bowel, Kidney disease, Liver disease, Metabolic syndrome, Migraine, Mood disorders, Motion sickness, Multiple sclerosis, Nausea, Neurodegeneration, Neuropathic pain, Obesity, OCD, Osteoporosis, Parkinson’s, Prion/Mad Cow disease, PTSD, Rheumatism, Schizophrenia, Sickle cell anemia, Skin conditions, Sleep disorders, Spinal cord injury, Stress, & Stroke/TBI (CBD Medical Studies are listed at this link in alphabetical order for these conditions). ​